RESUMO
Few reports exist on allergic reactions to ranitidine. We present a case of bronchospastic reaction to ranitidine occurred during a drug challenge test. After administration of a therapeutic dose of ranitidine, the patient showed dyspnea, cough and bronchospasm in all the lung fields. Personal respiratory background was negative for respiratory disease and asthma. On reviewing the literature we found no reports of bronchospastic reaction to ranitidine. Quickness and the clinical characteristics of the adverse reaction suggest a pathogenic mechanism of immediate-type hypersensitivity.
Assuntos
Antiulcerosos/efeitos adversos , Hipersensibilidade a Drogas/etiologia , Antagonistas dos Receptores H2 da Histamina/efeitos adversos , Ranitidina/efeitos adversos , Hipersensibilidade Respiratória/etiologia , Antiulcerosos/uso terapêutico , Asma , Refluxo Gastroesofágico/tratamento farmacológico , Antagonistas dos Receptores H2 da Histamina/uso terapêutico , Humanos , Testes Intradérmicos , Masculino , Pessoa de Meia-Idade , Ranitidina/uso terapêutico , RiniteRESUMO
BACKGROUND: There are few references of allergic reaction to beans in childhood. We report the case of a seven years old boy who suffered from angioedema associated to inhalation of vapours from cooked white bean. METHODS: skin prick tests (SPT) were performed by prick-by-prick with cooked white bean and legumes. It was also determined total IgE and specific IgE antibodies to bean and legumes with the use of the CAP enzymo-immunoassay. Subsequently, a oral challenge test was carried out with white bean. RESULTS: The prick-by-prick with white bean was positive in our case, and negative in ten controls patients. Specific IgE in patient serum, assayed by CAP was positive for white bean and green bean. The patient developed angioedema after ingestion cooked white bean. CONCLUSION: we demonstrated a type I hypersensitivity to white bean in a seven years old child by SPT, specific IgE antibodies and challenge test.
Assuntos
Angioedema/etiologia , Antígenos de Plantas/efeitos adversos , Hipersensibilidade Alimentar/etiologia , Gases/efeitos adversos , Hipersensibilidade Imediata/etiologia , Phaseolus/efeitos adversos , Doença Aguda , Especificidade de Anticorpos , Criança , Culinária , Exposição Ambiental , Hipersensibilidade Alimentar/imunologia , Humanos , Hipersensibilidade Imediata/imunologia , Imunoglobulina E/sangue , Imunoglobulina E/imunologia , Inalação , Masculino , Extratos Vegetais/efeitos adversos , Testes CutâneosRESUMO
A number of allergic, infectious and idiopathic diseases are associated with an increased number of eosinophils in blood. We report the case of a woman who was referred to our outpatient clinic due to asthma that had first developed three months previously and papular rash. Laboratory investigations revealed eosinophilia (23 %; 2,162 cells/ml). An allergic cause was ruled out by anamnesis, skin prick-test and specific IgE determination. Another frequent cause of eosinophilia is infestation by parasitic helminths, but serologic studies and studies of parasites in feces were negative. Chest radiography and computed tomography scan revealed diffuse infiltrates. The diagnosis was confirmed by transbronchial and skin lesion biopsies. The patient was finally diagnosed with Churg-Strauss syndrome and was treated with oral corticosteroids. A delay in the diagnosis and treatment of this syndrome increases the risk of death from the complications of vasculitis. Because of the importance of an early diagnosis in this disease, its presence should be suspected in cases of eosinophilia after ruling out more frequent causes.
